Tackling cancer cell dormancy: Insights from immune models, and transplantation.
Semin Cancer Biol
; 78: 5-16, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-33582171
ABSTRACT
Disseminated non-dividing (dormant) cancer cells as well as those in equilibrium with the immune response remain the major challenge for successful treatment of cancer. The equilibrium between disseminated dormant cancer cells and the immune system is reminiscent of states that can occur during infection or allogeneic tissue and cell transplantation. We discuss here the major competing models of how the immune system achieves a self nonself discrimination (pathogen/danger patterns, quorum, and coinhibition/tuning models), and suggest that taking advantage of a combination of the proposed mechanisms in each model may lead to increased efficacy in tackling cancer cell dormancy.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Suscetibilidade a Doenças
/
Microambiente Tumoral
/
Modelos Biológicos
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Semin Cancer Biol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2022
Tipo de documento:
Article