Different patterns of rotational behavior in rats after dorsal or ventral striatal lesions with ibotenic acid.
Pharmacol Biochem Behav
; 29(2): 403-6, 1988 Feb.
Article
em En
| MEDLINE
| ID: mdl-3362934
ABSTRACT
Rats with total, dorsal or ventral ibotenic acid striatal lesions were challenged with DA agonists apomorphine and d-amphetamine. In rats with total lesions, both drugs induced an intense ipsilateral rotation, as did apomorphine in the dorsally lesioned rats. Amphetamine induced ipsilateral rotation in ventrally lesioned rats, but this effect may represent a non-specific potentiation of spontaneous ipsilateral rotation observed in this group. These results indicate that the neostriatum of the rat is not an homogeneous structure concerning the expression of rotational behavior after DA receptor stimulation.
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Base de dados:
MEDLINE
Assunto principal:
Oxazóis
/
Comportamento Animal
/
Corpo Estriado
/
Ácido Ibotênico
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Grécia