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Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus, Christoph; Luecken, Malte D; Eraslan, Gökcen; Sikkema, Lisa; Waghray, Avinash; Heimberg, Graham; Kobayashi, Yoshihiko; Vaishnav, Eeshit Dhaval; Subramanian, Ayshwarya; Smillie, Christopher; Jagadeesh, Karthik A; Duong, Elizabeth Thu; Fiskin, Evgenij; Torlai Triglia, Elena; Ansari, Meshal; Cai, Peiwen; Lin, Brian; Buchanan, Justin; Chen, Sijia; Shu, Jian; Haber, Adam L; Chung, Hattie; Montoro, Daniel T; Adams, Taylor; Aliee, Hananeh; Allon, Samuel J; Andrusivova, Zaneta; Angelidis, Ilias; Ashenberg, Orr; Bassler, Kevin; Bécavin, Christophe; Benhar, Inbal; Bergenstråhle, Joseph; Bergenstråhle, Ludvig; Bolt, Liam; Braun, Emelie; Bui, Linh T; Callori, Steven; Chaffin, Mark; Chichelnitskiy, Evgeny; Chiou, Joshua; Conlon, Thomas M; Cuoco, Michael S; Cuomo, Anna S E; Deprez, Marie; Duclos, Grant; Fine, Denise; Fischer, David S; Ghazanfar, Shila; Gillich, Astrid.
Afiliação
  • Muus C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. muus@broadinstitute.org.
  • Luecken MD; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. muus@broadinstitute.org.
  • Eraslan G; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany. malte.luecken@helmholtz-muenchen.de.
  • Sikkema L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Waghray A; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
  • Heimberg G; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Kobayashi Y; Departments of Internal Medicine and Pediatrics, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Vaishnav ED; Harvard Stem Cell Institute, Cambridge, MA, USA.
  • Subramanian A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Smillie C; Department of Cell Biology, Duke University Medical School, Durham, NC, USA.
  • Jagadeesh KA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Duong ET; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Fiskin E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Torlai Triglia E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Ansari M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Cai P; Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
  • Lin B; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Buchanan J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Chen S; Comprehensive Pneumology Center (CPC)/Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
  • Shu J; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany.
  • Haber AL; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Chung H; Departments of Internal Medicine and Pediatrics, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Montoro DT; Harvard Stem Cell Institute, Cambridge, MA, USA.
  • Adams T; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Aliee H; Center for Epigenomics, University of California San Diego School of Medicine, La Jolla, CA, USA.
  • Allon SJ; Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA.
  • Andrusivova Z; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Angelidis I; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Ashenberg O; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
  • Bassler K; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bécavin C; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Benhar I; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bergenstråhle J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bergenstråhle L; Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Bolt L; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany.
  • Braun E; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bui LT; Institute for Medical Engineering and Science & Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Callori S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Chaffin M; SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockolm, Sweden.
  • Chichelnitskiy E; Comprehensive Pneumology Center (CPC)/Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
  • Chiou J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Conlon TM; Department for Genomics & Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany.
  • Cuoco MS; Université Côte d'Azur, CNRS, IPMC, Sophia-Antipolis, France.
  • Cuomo ASE; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Deprez M; SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockolm, Sweden.
  • Duclos G; SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockolm, Sweden.
  • Fine D; Wellcome Sanger Institute, Hinxton, UK.
  • Fischer DS; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
  • Ghazanfar S; Translational Genomics Research Institute, Phoenix, AZ, USA.
  • Gillich A; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Nat Med ; 27(3): 546-559, 2021 03.
Article em En | MEDLINE | ID: mdl-33654293
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise de Sequência de RNA / Internalização do Vírus / Interações Hospedeiro-Patógeno / Análise de Célula Única / SARS-CoV-2 / COVID-19 Tipo de estudo: Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise de Sequência de RNA / Internalização do Vírus / Interações Hospedeiro-Patógeno / Análise de Célula Única / SARS-CoV-2 / COVID-19 Tipo de estudo: Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos