Curcumin protects BEAS2B cells from PM2.5induced oxidative stress and inflammation by activating NRF2/antioxidant response element pathways.
Int J Mol Med
; 47(4)2021 04.
Article
em En
| MEDLINE
| ID: mdl-33655321
ABSTRACT
Fine particulate matter (PM2.5) with an average aerodynamic diameter of <2.5 µm can cause severe lung injury. Oxidative stress and inflammation are considered the main outcomes of PM2.5 exposure. Curcumin is a wellknown antioxidant; however, its effect on PM2.5induced oxidative injury in airway epithelial cells remains unclear. In the present study, it was demonstrated that pretreatment with curcumin significantly reduced the PM2.5induced apoptosis of BEAS2B human bronchial epithelial cells by decreasing the level of intercellular reactive oxygen species. Western blot analysis revealed that curcumin increased the expression of nuclear factor erythroid 2related factor 2 (NRF2) and regulated the transcription of downstream genes, particularly those encoding antioxidant enzymes. Moreover, curcumin reduced the PM2.5induced expression and production of inflammatory factors, and induced the expression of the antiinflammatory factors, interleukin (IL)5 and IL13. Taken together, the present study demonstrates that curcumin protects BEAS2B cells against PM2.5induced oxidative damage and inflammation, and prevents cell apoptosis by increasing the activation of NRF2related pathways. It is thus suggested that curcumin may be a potential compound for use in the prevention of PM2.5induced tissue injury.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
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Curcumina
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Fator 2 Relacionado a NF-E2
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Material Particulado
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Lesão Pulmonar
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Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
Int J Mol Med
Assunto da revista:
BIOLOGIA MOLECULAR
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GENETICA MEDICA
Ano de publicação:
2021
Tipo de documento:
Article