Peroxide- and transition metal-free electrochemical synthesis of &#945;,ß-epoxy ketones.

Zhang, Mengxun; Chen, Tie; Fang, Shisong; Wu, Weihua; Wang, Xin; Wu, Haiqiang; Xiong, Yongai; Song, Jun; Li, Chenyang; He, Zhendan; Lee, Chi-Sing

Peroxide- and transition metal-free electrochemical synthesis of α,ß-epoxy ketones.

Zhang, Mengxun; Chen, Tie; Fang, Shisong; Wu, Weihua; Wang, Xin; Wu, Haiqiang; Xiong, Yongai; Song, Jun; Li, Chenyang; He, Zhendan; Lee, Chi-Sing.

Afiliação

Zhang M; Department of Pharmacy, School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China. hezhendan@szu.edu.cn and College of physics and optoelectronic engineering, Shenzhen University, Shenzhen 518060, China.
Chen T; Department of Pharmacy, School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China. hezhendan@szu.edu.cn.
Fang S; Shenzhen Center for Disease Control and Prevention, Shenzhen 518100, China.
Wu W; Shenzhen Center for Disease Control and Prevention, Shenzhen 518100, China.
Wang X; Shenzhen Center for Disease Control and Prevention, Shenzhen 518100, China.
Wu H; Department of Pharmacy, School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China. hezhendan@szu.edu.cn.
Xiong Y; Department of Pharmacy, School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China. hezhendan@szu.edu.cn.
Song J; College of physics and optoelectronic engineering, Shenzhen University, Shenzhen 518060, China.
Li C; Department of Pharmacy, School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China. hezhendan@szu.edu.cn.
He Z; Department of Pharmacy, School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China. hezhendan@szu.edu.cn and College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Lee CS; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.

Org Biomol Chem ; 19(11): 2481-2486, 2021 03 21.

Article em En | MEDLINE | ID: mdl-33656035

ABSTRACT

ABSTRACT

A novel electrochemical method for the synthesis of α,ß-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded α,ß-epoxy ketones in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,ß-epoxy ketones in gram-scales for evaluation of their anti-cancer activities.

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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