[Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease].
Sheng Li Xue Bao
; 73(1): 89-102, 2021 Feb 25.
Article
em Zh
| MEDLINE
| ID: mdl-33665664
ABSTRACT
Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). Genetic vulnerability, aging, environmental insults are believed to contribute to the pathogenesis of PD. However, the cellular and molecular mechanism of dopaminergic neurons degeneration remains incompletely understood. Dopamine (DA) metabolism is a cardinal physiological process in dopaminergic neurons, which is closely related to the loss of dopaminergic neurons in the SN. DA metabolism takes part in several pathological processes of PD neurodegeneration, such as iron metabolism disturbance, α-synuclein mis-folding, endoplasmic reticulum stress, protein degradation dysfunction, neuroinflammatory response, etc. In this review, we will describe altered DA metabolism and its contributions to PD pathogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China