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Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886).
Yeh, Yao-Tsung; Lin, Sung-Chun; Lee, Gene-Hsiang; Wen, Zhi-Hong; Hwang, Tsong-Long; Wu, Yu-Jen; Chen, Jih-Jung; Fang, Lee-Shing; Yuan, Mei-Kang; Sung, Ping-Jyun.
Afiliação
  • Yeh YT; Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan.
  • Lin SC; National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan.
  • Lee GH; Department of Orthopaedic Surgery, Ping-Tung Christian Hospital, Pingtung 900026, Taiwan.
  • Wen ZH; Instrumentation Center, National Taiwan University, Taipei 106319, Taiwan.
  • Hwang TL; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
  • Wu YJ; Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
  • Chen JJ; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.
  • Fang LS; Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.
  • Yuan MK; Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.
  • Sung PJ; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan.
Mar Drugs ; 19(3)2021 Feb 27.
Article em En | MEDLINE | ID: mdl-33673526
ABSTRACT
Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antozoários / Diterpenos / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Taiwan
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antozoários / Diterpenos / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Taiwan