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Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.
Hoffmann, Markus; Hofmann-Winkler, Heike; Smith, Joan C; Krüger, Nadine; Arora, Prerna; Sørensen, Lambert K; Søgaard, Ole S; Hasselstrøm, Jørgen Bo; Winkler, Michael; Hempel, Tim; Raich, Lluís; Olsson, Simon; Danov, Olga; Jonigk, Danny; Yamazoe, Takashi; Yamatsuta, Katsura; Mizuno, Hirotaka; Ludwig, Stephan; Noé, Frank; Kjolby, Mads; Braun, Armin; Sheltzer, Jason M; Pöhlmann, Stefan.
Afiliação
  • Hoffmann M; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, 37073 Göttingen, Germany. Electronic address: mhoffmann@dpz.eu.
  • Hofmann-Winkler H; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
  • Smith JC; Google, Inc., New York City, NY 10011, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Krüger N; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
  • Arora P; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, 37073 Göttingen, Germany.
  • Sørensen LK; Department of Forensic Medicine, Aarhus University, 8200 Aarhus, Denmark.
  • Søgaard OS; Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark; Department of Infectious Diseases, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Hasselstrøm JB; Department of Forensic Medicine, Aarhus University, 8200 Aarhus, Denmark.
  • Winkler M; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
  • Hempel T; Freie Universität Berlin, Department of Mathematics and Computer Science, Berlin, Germany; Freie Universität Berlin, Department of Physics, Berlin, Germany.
  • Raich L; Freie Universität Berlin, Department of Mathematics and Computer Science, Berlin, Germany.
  • Olsson S; Freie Universität Berlin, Department of Mathematics and Computer Science, Berlin, Germany; Chalmers University of Technology, Department of Computer Science and Engineering, Göteborg, Sweden.
  • Danov O; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR), Nikolai-Fuchs-St
  • Jonigk D; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR), Nikolai-Fuchs-St
  • Yamazoe T; Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan.
  • Yamatsuta K; Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan.
  • Mizuno H; Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan.
  • Ludwig S; Institute of Virology (IVM), Westfälische Wilhelms-Universität, 48149 Münster, Germany; Cluster of Excellence "Cells in Motion", Westfälische Wilhelms-Universität, 48149 Münster, Germany.
  • Noé F; Freie Universität Berlin, Department of Mathematics and Computer Science, Berlin, Germany; Freie Universität Berlin, Department of Physics, Berlin, Germany; Rice University, Department of Chemistry, Houston, TX, USA.
  • Kjolby M; Danish Diabetes Academy and DANDRITE, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Braun A; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR), Nikolai-Fuchs-St
  • Sheltzer JM; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Pöhlmann S; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, 37073 Göttingen, Germany. Electronic address: spoehlmann@dpz.eu.
EBioMedicine ; 65: 103255, 2021 Mar.
Article em En | MEDLINE | ID: mdl-33676899
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Serina Endopeptidases / Ésteres / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 / Guanidinas Limite: Animals / Humans Idioma: En Revista: EBioMedicine Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Serina Endopeptidases / Ésteres / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 / Guanidinas Limite: Animals / Humans Idioma: En Revista: EBioMedicine Ano de publicação: 2021 Tipo de documento: Article