Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.

Silman, Israel; Shnyrov, Valery L; Ashani, Yacov; Roth, Esther; Nicolas, Anne; Sussman, Joel L; Weiner, Lev

Silman, Israel; Shnyrov, Valery L; Ashani, Yacov; Roth, Esther; Nicolas, Anne; Sussman, Joel L; Weiner, Lev.

Afiliação

Silman I; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Shnyrov VL; Department of Biochemistry and Molecular Biology, Universidad de Salamanca, Salamanca, Spain.
Ashani Y; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Roth E; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Nicolas A; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Sussman JL; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Weiner L; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.

Protein Sci ; 30(5): 966-981, 2021 05.

Article em En | MEDLINE | ID: mdl-33686648

Assuntos

Acetilcolinesterase/química; Proteínas de Peixes/química; Torpedo; Animais; Sítios de Ligação; Cátions Bivalentes/química; Cristalografia por Raios X; Estabilidade Enzimática; Metais/química

Palavras-chave

crystal structures; differential scanning calorimetry; divalent metal ion; electron paramagnetic resonance; thermal inactivation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Torpedo / Proteínas de Peixes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Protein Sci Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Israel

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