Your browser doesn't support javascript.
loading
Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.
Rademakers, Rosa; Nicholson, Alexandra M; Ren, Yingxue; Koga, Shunsuke; Nguyen, Hung Phuoc; Brooks, Mieu; Qiao, Wenhui; Quicksall, Zachary S; Matchett, Billie; Perkerson, Ralph B; Kurti, Aishe; Castanedes-Casey, Monica; Phillips, Virginia; Librero, Ariston L; Fernandez De Castro, Cristhoper H; Baker, Matthew C; Roemer, Shanu F; Murray, Melissa E; Asmann, Yan; Fryer, John D; Bu, Guojun; Dickson, Dennis W; Zhou, Xiaolai.
Afiliação
  • Rademakers R; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Nicholson AM; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
  • Ren Y; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
  • Koga S; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Nguyen HP; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
  • Brooks M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Qiao W; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Quicksall ZS; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Matchett B; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Perkerson RB; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
  • Kurti A; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Castanedes-Casey M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Phillips V; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Librero AL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Fernandez De Castro CH; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Baker MC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Roemer SF; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Asmann Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Fryer JD; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Bu G; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
  • Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Zhou X; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Brain Pathol ; 31(3): e12945, 2021 05.
Article em En | MEDLINE | ID: mdl-33709463
ABSTRACT
TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células de Purkinje Limite: Animals Idioma: En Revista: Brain Pathol Assunto da revista: CEREBRO / PATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células de Purkinje Limite: Animals Idioma: En Revista: Brain Pathol Assunto da revista: CEREBRO / PATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos