Expression of Hedgehog signalling molecules in microcystic adnexal carcinoma.
Clin Exp Dermatol
; 46(6): 1052-1057, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-33714217
ABSTRACT
BACKGROUND:
Microcystic adnexal carcinoma (MAC) is a rare skin neoplasm that has not been characterized on a molecular basis.AIM:
To assess expression profiles of Hedgehog (HH) signalling molecules in MAC and control tumours.METHODS:
Immunohistochemistry was performed for Sonic Hedgehog (SHH), Indian Hedgehog (IHH), Patched 1 (PTCH1) and Smoothened (SMO) on patient MAC tissue (n = 26) and control tumour tissue, including syringoma (SyG; n = 11), trichoepithelioma (TE; n = 11) and basal cell carcinoma (BCC; n = 12) tissues.RESULTS:
Patched 1 and SMO immunoreactivity was significantly higher in BCC than in SyG, TE or MAC (P < 0.001 and P < 0.03, respectively). The highest IHH expression was observed in BCC and TE compared with SyG and MAC (P < 0.04). Notably, the highest SHH protein expression was observed in SyG compared with MAC, TE and even BCC (P < 0.001). In patients with MAC, SMO immunoreactivity significantly (r = 0.51; P < 0.01) correlated with PTCH1 expression. Further correlation studies did not show significant associations between the HH expression markers assessed (P > 0.05).CONCLUSION:
Our results indicate that alterations of the HH signalling are unlikely to play a major role in the pathogenesis of MAC, which is in contrast to the morphologically similar BCC and TE. Our observation provides additional information to the limited molecular pathology knowledge on this rare tumour.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Transdução de Sinais
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Neoplasias de Anexos e de Apêndices Cutâneos
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Proteínas Hedgehog
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Exp Dermatol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha