ADAMTS proteases and the tumor immune microenvironment: Lessons from substrates and pathologies.
Matrix Biol Plus
; 9: 100054, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33718860
ABSTRACT
The relationship of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteases with inflammatory processes was anticipated since their discovery. Although knowledge of these extracellular proteases in different contexts continues to grow, many questions remain unanswered. In this review, we summarize the most important studies of ADAMTSs and their substrates in inflammation and in the immune system of non-oncological disorders. In addition, we update the findings on cancer and highlight their emerging role in the tumor immune microenvironment. Although the overall functions of extracellular molecules are known to be modulated by proteolysis, specific activities attributed to intact proteins and cleaved fragments in the context of inflammation are still subject to debate. A better understanding of ADAMTS activities will help to elucidate their contribution to the immune phenotype and to open up new therapeutic and diagnostic possibilities.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Matrix Biol Plus
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Espanha