Both IRBIT and long-IRBIT bind to and coordinately regulate Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal degradation of AE2.

Itoh, Ryo; Hatano, Naoya; Murakami, Momoko; Mitsumori, Kosuke; Kawasaki, Satoko; Wakagi, Tomoka; Kanzaki, Yoshino; Kojima, Hiroyuki; Kawaai, Katsuhiro; Mikoshiba, Katsuhiko; Hamada, Koichi; Mizutani, Akihiro

Both IRBIT and long-IRBIT bind to and coordinately regulate Cl^-/HCO₃^- exchanger AE2 activity through modulating the lysosomal degradation of AE2.

Itoh, Ryo; Hatano, Naoya; Murakami, Momoko; Mitsumori, Kosuke; Kawasaki, Satoko; Wakagi, Tomoka; Kanzaki, Yoshino; Kojima, Hiroyuki; Kawaai, Katsuhiro; Mikoshiba, Katsuhiko; Hamada, Koichi; Mizutani, Akihiro.

Afiliação

Itoh R; Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Hatano N; Division of Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, 700-8530, Japan.
Murakami M; Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Mitsumori K; Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Kawasaki S; Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Wakagi T; Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Kanzaki Y; Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Kojima H; Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Kawaai K; Laboratory of Cell and Tissue Biology, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Mikoshiba K; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, China.
Hamada K; Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Mizutani A; Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan. mizutani@ac.shoyaku.ac.jp.

Sci Rep ; 11(1): 5990, 2021 03 16.

Article em En | MEDLINE | ID: mdl-33727633

Assuntos

Antiportadores de Cloreto-Bicarbonato/metabolismo; Ativação do Canal Iônico; Lectinas Tipo C/metabolismo; Lisossomos/metabolismo; Proteínas de Membrana/metabolismo; Motivos de Aminoácidos; Sequência de Aminoácidos; Animais; Bicarbonatos/metabolismo; Transporte Biológico; Linhagem Celular; Antiportadores de Cloreto-Bicarbonato/química; Cloretos/metabolismo; Técnicas de Silenciamento de Genes; Humanos; Lectinas Tipo C/química; Lectinas Tipo C/genética; Melanoma Experimental; Proteínas de Membrana/química; Proteínas de Membrana/genética; Camundongos; Ligação Proteica; Domínios e Motivos de Interação entre Proteínas; Isoformas de Proteínas; Multimerização Proteica; Proteólise; Estresse Fisiológico

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação do Canal Iônico / Antiportadores de Cloreto-Bicarbonato / Lectinas Tipo C / Lisossomos / Proteínas de Membrana Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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