Classification of high-grade cervical intraepithelial neoplasia by p16<sup>ink4a</sup> , Ki-67, HPV E4 and FAM19A4/miR124-2 methylation status demonstrates considerable heterogeneity with potential consequences for management.

Vink, Frederique J; Dick, Stèfanie; Heideman, Daniëlle A M; De Strooper, Lise M A; Steenbergen, Renske D M; Lissenberg-Witte, Birgit I; Floore, Arno; Bonde, Jesper H; Ostrbenk Valencak, Anja; Poljak, Mario; Petry, Karl U; Hillemanns, Peter; van Trommel, Nienke E; Berkhof, Johannes; Bleeker, Maaike C G; Meijer, Chris J L M

Classification of high-grade cervical intraepithelial neoplasia by p16^ink4a , Ki-67, HPV E4 and FAM19A4/miR124-2 methylation status demonstrates considerable heterogeneity with potential consequences for management.

Vink, Frederique J; Dick, Stèfanie; Heideman, Daniëlle A M; De Strooper, Lise M A; Steenbergen, Renske D M; Lissenberg-Witte, Birgit I; Floore, Arno; Bonde, Jesper H; Ostrbenk Valencak, Anja; Poljak, Mario; Petry, Karl U; Hillemanns, Peter; van Trommel, Nienke E; Berkhof, Johannes; Bleeker, Maaike C G; Meijer, Chris J L M.

Afiliação

Vink FJ; Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Dick S; Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Heideman DAM; Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
De Strooper LMA; Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Steenbergen RDM; Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Lissenberg-Witte BI; Department of Epidemiology and Data Science, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Floore A; Self-screen B.V., Amsterdam, The Netherlands.
Bonde JH; Molecular Pathology Laboratory, Department of Pathology, Hvidovre Hospital, Hvidovre, Denmark.
Ostrbenk Valencak A; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Poljak M; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Petry KU; Department of Gynecologic Oncology, Klinikum Wolfsburg, Wolfsburg, Germany.
Hillemanns P; Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
van Trommel NE; Antoni van Leeuwenhoek, Netherlands Cancer Institute, Department of Gynecologic Oncology, Centre of Gynecologic Oncology Amsterdam, Amsterdam, The Netherlands.
Berkhof J; Department of Epidemiology and Data Science, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Bleeker MCG; Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Meijer CJLM; Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Int J Cancer ; 149(3): 707-716, 2021 08 01.

Article em En | MEDLINE | ID: mdl-33729551

Assuntos

Inibidor p16 de Quinase Dependente de Ciclina/metabolismo; Citocinas/metabolismo; Metilação de DNA; Antígeno Ki-67/metabolismo; MicroRNAs/genética; Proteínas Oncogênicas Virais/metabolismo; Displasia do Colo do Útero/patologia; Neoplasias do Colo do Útero/patologia; Adulto; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Inibidor p16 de Quinase Dependente de Ciclina/genética; Citocinas/genética; Gerenciamento Clínico; Feminino; Seguimentos; Regulação Neoplásica da Expressão Gênica; Humanos; Antígeno Ki-67/genética; Proteínas Oncogênicas Virais/genética; Prognóstico; Estudos Prospectivos; Neoplasias do Colo do Útero/classificação; Neoplasias do Colo do Útero/genética; Neoplasias do Colo do Útero/metabolismo; Displasia do Colo do Útero/classificação; Displasia do Colo do Útero/genética; Displasia do Colo do Útero/metabolismo

Palavras-chave

DNA hypermethylation; HPV E4 protein; Ki-67; cervical cancer; cervical precancer; human papillomavirus; immunohistochemistry; p16ink4a; productive HPV infection; transforming HPV infection

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Displasia do Colo do Útero / Neoplasias do Colo do Útero / Proteínas Oncogênicas Virais / Citocinas / Antígeno Ki-67 / Metilação de DNA / Inibidor p16 de Quinase Dependente de Ciclina / MicroRNAs Tipo de estudo: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda

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