Peripheral bright streaks in tuberous sclerosis.
Am J Ophthalmol Case Rep
; 22: 101050, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33732948
ABSTRACT
PURPOSE:
To describe the finding of bright hyperautofluorescent streaks in the peripheral retina in tuberous sclerosis. OBSERVATIONS A woman with a pathogenic TSC1 mutation and cutaneous manifestations of tuberous sclerosis underwent fundus examination and was found to have a cluster of thin, yellowish streaks in the inferior peripheral fundus of her left eye. The streaks were hyperautofluorescent in blue light and associated with irregular thickening of the photoreceptor-pigment epithelium complex on optical coherence tomography. CONCLUSIONS AND IMPORTANCE The cluster of outer retinal abnormalities in a sector of the peripheral retina in one eye of a TSC1 patient has features in common with the more centrally located and less numerous lesions called achromatic patches. The resemblance of the streak pattern with the pattern of hypoautofluorescence in X-linked retinopathies suggests that the streaks may represent a clone of cells derived from a single somatic mutation in TSC1. The identification of this lesion type expands the scope of conditions that can be diagnosed by fundus imaging.
Texto completo:
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Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Am J Ophthalmol Case Rep
Ano de publicação:
2021
Tipo de documento:
Article