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LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells.
Chen, Xiang; Pan, Li; Wei, Jia; Zhang, Ruijie; Yang, Xiaozhi; Song, Jinhua; Bai, Ren-Yuan; Fu, Shengling; Pierson, Christopher R; Finlay, Jonathan L; Li, Chenglong; Lin, Jiayuh.
Afiliação
  • Chen X; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
  • Pan L; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
  • Wei J; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
  • Zhang R; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
  • Yang X; Department of Medicinal Chemistry, College of Pharmacy, The University of Florida, Gainesville, FL, 32610, USA.
  • Song J; Department of Medicinal Chemistry, College of Pharmacy, The University of Florida, Gainesville, FL, 32610, USA.
  • Bai RY; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
  • Fu S; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
  • Pierson CR; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, The Department of Pathology and Department of Biomedical Education and Anatomy, The College of Medicine, The Ohio State University, Columbus, OH, 43205, USA.
  • Finlay JL; Division of Hematology, Oncology and BMT, Department of Pediatrics, College of Medicine, The Research Institute At Nationwide Children's Hospital, The Ohio State University, Columbus, OH, 43205, USA.
  • Li C; Department of Medicinal Chemistry, College of Pharmacy, The University of Florida, Gainesville, FL, 32610, USA. lic@cop.ufl.edu.
  • Lin J; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. JLin@som.umaryland.edu.
Sci Rep ; 11(1): 6517, 2021 03 22.
Article em En | MEDLINE | ID: mdl-33753770
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Antraquinonas / Interferon gama / Fator de Transcrição STAT1 / Fator de Transcrição STAT3 / Meduloblastoma Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Antraquinonas / Interferon gama / Fator de Transcrição STAT1 / Fator de Transcrição STAT3 / Meduloblastoma Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos