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A new perspective on the immune escape mechanism in HCC: onco-foetal reprogramming.
Chew, Sin Chi; Choo, Si Ying; Chow, Pierce Kah-Hoe.
Afiliação
  • Chew SC; Programme in Translational and Clinical Liver Research, Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
  • Choo SY; Programme in Translational and Clinical Liver Research, Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
  • Chow PK; Programme in Translational and Clinical Liver Research, Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore. pierce.chow.k.h@singhealth.com.sg.
Br J Cancer ; 124(12): 1897-1899, 2021 06.
Article em En | MEDLINE | ID: mdl-33767421
ABSTRACT
We found a shared immunosuppressive microenvironment between foetal liver and hepatocellular carcinoma (HCC) which includes the re-emergence of foetal-associated endothelial cells (PLVAP/VEGFR2) and foetal-like (FOLR2) tumour-associated macrophages in HCC, mediated via VEGF-NOTCH signalling. The discoveries suggest possible novel targets for therapeutic interventions in HCC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Evasão Tumoral / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Revista: Br J Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Evasão Tumoral / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Revista: Br J Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura