A new perspective on the immune escape mechanism in HCC: onco-foetal reprogramming.
Br J Cancer
; 124(12): 1897-1899, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33767421
ABSTRACT
We found a shared immunosuppressive microenvironment between foetal liver and hepatocellular carcinoma (HCC) which includes the re-emergence of foetal-associated endothelial cells (PLVAP/VEGFR2) and foetal-like (FOLR2) tumour-associated macrophages in HCC, mediated via VEGF-NOTCH signalling. The discoveries suggest possible novel targets for therapeutic interventions in HCC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
/
Evasão Tumoral
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Neoplasias Hepáticas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Singapura