Identification of the protective effect of <i>Polygonatum sibiricum</i> polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network.

Zhang, Zheyu; Yang, Bo; Huang, Jianhua; Li, Wenqun; Yi, Pengji; Yi, Min; Peng, Weijun

Identification of the protective effect of Polygonatum sibiricum polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network.

Zhang, Zheyu; Yang, Bo; Huang, Jianhua; Li, Wenqun; Yi, Pengji; Yi, Min; Peng, Weijun.

Afiliação

Zhang Z; Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Yang B; Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, China.
Huang J; Hunan Academy of Chinese Medicine, Changsha, PR China.
Li W; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Yi P; Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Yi M; Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Peng W; Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Pharm Biol ; 59(1): 347-366, 2021 Dec.

Article em En | MEDLINE | ID: mdl-33794121

Assuntos

Encéfalo/efeitos dos fármacos; Polygonatum/química; Polissacarídeos/farmacologia; RNA Circular/genética; Envelhecimento/efeitos dos fármacos; Animais; Comportamento Animal/efeitos dos fármacos; Encéfalo/patologia; Relação Dose-Resposta a Droga; Galactose; Perfilação da Expressão Gênica; Masculino; Aprendizagem em Labirinto/efeitos dos fármacos; Camundongos; MicroRNAs/genética; Polissacarídeos/administração & dosagem; Polissacarídeos/isolamento & purificação; RNA Mensageiro/genética

Palavras-chave

Natural bioactive substances; RNA sequencing; anti-ageing; ceRNA theory; circRNA; synapse

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polissacarídeos / Encéfalo / Polygonatum / RNA Circular Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Pharm Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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