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Interleukin-6 in Amniotic Fluid: A Reliable Marker for Adverse Outcomes in Women in Preterm Labor and Intact Membranes.
Leaños-Miranda, Alfredo; Nolasco-Leaños, Ana Graciela; Carrillo-Juárez, Reyes Ismael; Molina-Pérez, Carlos José; Isordia-Salas, Irma; Ramírez-Valenzuela, Karla Leticia.
Afiliação
  • Leaños-Miranda A; Unidad de Investigación Médica en Medicina Reproductiva, UMAE-Hospital de Ginecología y Obstetricia "Luis Castelazo Ayala," Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
  • Nolasco-Leaños AG; Unidad de Investigación Médica en Medicina Reproductiva, UMAE-Hospital de Ginecología y Obstetricia "Luis Castelazo Ayala," Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
  • Carrillo-Juárez RI; Posgrado e Investigación Biomedicina y Biotecnología Molecular, Instituto Politécnico Nacional, Ciudad de Mexico, Mexico.
  • Molina-Pérez CJ; Unidad de Investigación Médica en Medicina Reproductiva, UMAE-Hospital de Ginecología y Obstetricia "Luis Castelazo Ayala," Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
  • Isordia-Salas I; Unidad de Investigación Médica en Medicina Reproductiva, UMAE-Hospital de Ginecología y Obstetricia "Luis Castelazo Ayala," Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
  • Ramírez-Valenzuela KL; Unidad de Investigación en Trombosis, Hemostasia y Aterogénesis, HGR No.1 "Dr. Carlos Mac Gregor," Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
Fetal Diagn Ther ; 48(4): 313-320, 2021.
Article em En | MEDLINE | ID: mdl-33794521
INTRODUCTION: Amniotic fluid (AF) interleukin-6 (IL-6) concentration has been associated to preterm delivery and perinatal morbidity and mortality in women with preterm labor and intact membranes. Nevertheless, the clinical significance of this biomarker of intra-amniotic inflammation (IAI) is still unclear due in part to the paucity of large studies. METHODS: AF IL-6 concentrations were determined in 452 consecutive women with preterm labor and intact membranes, categorized into 3 groups: 302 without IAI (IL-6 of <2.6 ng/mL), 64 with mild IAI (IL-6 of 2.6-11.2 ng/mL), and 86 with severe IAI (IL-6 of ≥11.3 ng/mL). RESULTS: The severe IAI group had a short pregnancy duration from amniocentesis to delivery (median 3 days) than in without IAI group (median 45 days); meanwhile, the mild IAI group had a latency that was intermediate to the severe and without IAI groups (median 9.5 days). As compared to women without IAI, women with mild and severe IAI had higher rates of preterm delivery at both <34 and <37 weeks of gestation and perinatal morbidity and mortality. Furthermore, the risk of various individual adverse outcomes (short latency from amniocentesis to delivery [at ≤3 days, ≤7 days, and ≤14 days], preterm delivery at both <34 and <37 weeks of gestation, histologic chorioamnionitis, respiratory distress syndrome, and congenital sepsis) was higher in women with severe IAI (OR ≥ 2.8), compared with women without IAI. CONCLUSIONS: AF IL-6 concentrations appear to be suitable marker to assess the degree of IAI and are associated with increased risk of adverse outcomes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corioamnionite / Trabalho de Parto Prematuro Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Fetal Diagn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / OBSTETRICIA / PERINATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corioamnionite / Trabalho de Parto Prematuro Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Fetal Diagn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / OBSTETRICIA / PERINATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México