Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators.

Pace, Simona; Zhang, Kehong; Jordan, Paul M; Bilancia, Rossella; Wang, Wenfei; Börner, Friedemann; Hofstetter, Robert K; Potenza, Marianna; Kretzer, Christian; Gerstmeier, Jana; Fischer, Dagmar; Lorkowski, Stefan; Gilbert, Nathaniel C; Newcomer, Marcia E; Rossi, Antonietta; Chen, Xinchun; Werz, Oliver

Pace, Simona; Zhang, Kehong; Jordan, Paul M; Bilancia, Rossella; Wang, Wenfei; Börner, Friedemann; Hofstetter, Robert K; Potenza, Marianna; Kretzer, Christian; Gerstmeier, Jana; Fischer, Dagmar; Lorkowski, Stefan; Gilbert, Nathaniel C; Newcomer, Marcia E; Rossi, Antonietta; Chen, Xinchun; Werz, Oliver.

Afiliação

Pace S; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany. Electronic address: simona.pace@uni-jena.de.
Zhang K; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, Shenzhen University School of Medicine, Shenzhen 51
Jordan PM; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany. Electronic address: paul.jordan@uni-jena.de.
Bilancia R; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy. Electronic address:
Wang W; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, Shenzhen University School of Medicine, Shenzhen 51
Börner F; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany.
Hofstetter RK; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany. Electronic address: robert.klaus.hofstetter@uni-jena.de.
Potenza M; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, I-84084 Fisciano, Italy. Electronic address: mpontenza@unisa.it.
Kretzer C; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany. Electronic address: Christian.kretzer@uni-jena.de.
Gerstmeier J; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany. Electronic address: jana.gerstmeier@uni-jena.de.
Fischer D; Department of Chemistry and Pharmacy, Pharmaceutical Technology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Cauerstrasse 4, 91058 Erlangen, Germany. Electronic address: dagmar.fischer@fau.de.
Lorkowski S; Department of Nutritional Biochemistry and Physiology, Institute of Nutritional Sciences, Friedrich Schiller University, Dornburger Str. 25, 07743 Jena, Germany; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Germany. Electronic address: stefan.lorkowski@u
Gilbert NC; Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA. Electronic address: ngilbert@lsu.edu.
Newcomer ME; Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA. Electronic address: newcomer@lsu.edu.
Rossi A; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy. Electronic address: antrossi@unina.it.
Chen X; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, Shenzhen University School of Medicine, Shenzhen 518000, China. Electronic address: chenxinchun@szu.edu.cn.
Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany. Electronic address: oliver.werz@uni-jena.de.

Pharmacol Res ; 167: 105556, 2021 05.

Article em En | MEDLINE | ID: mdl-33812006

Assuntos

Anti-Inflamatórios/farmacologia; Leucotrienos/metabolismo; Metabolismo dos Lipídeos/efeitos dos fármacos; Inibidores de Lipoxigenase/farmacologia; Triterpenos Pentacíclicos/farmacologia; Animais; Anti-Inflamatórios/química; Araquidonato 5-Lipoxigenase/metabolismo; Vias Biossintéticas/efeitos dos fármacos; Células Cultivadas; Humanos; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Inibidores de Lipoxigenase/química; Masculino; Camundongos; Simulação de Acoplamento Molecular; Triterpenos Pentacíclicos/química; Tripterygium/química

Palavras-chave

5-lipoxygenase; Celastrol; Inflammation; Leukotriene; MK886 (PubChem CID: 3651377); Specialized pro-resolving mediators; arachidonic acid (PubChem CID: 444899); celastrol (PubChem CID: 122724); celecoxib (PubChem CID: 2662); dimethyl sulfoxide (PubChem CID: 679); indomethacin (PubChem CID: 3715); resolvin D5 (PubChem CID: 16061139); zileuton (PubChem CID: 60490); zymosan (PubChem CID: 64689)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucotrienos / Inibidores de Lipoxigenase / Metabolismo dos Lipídeos / Triterpenos Pentacíclicos / Anti-Inflamatórios Limite: Animals / Humans / Male Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article

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