Engram cell connectivity: an evolving substrate for information storage.
Curr Opin Neurobiol
; 67: 215-225, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33812274
ABSTRACT
Understanding memory requires an explanation for how information can be stored in the brain in a stable state. The change in the brain that accounts for a given memory is referred to as an engram. In recent years, the term engram has been operationalized as the cells that are activated by a learning experience, undergoes plasticity, and are sufficient and necessary for memory recall. Using this framework, and a growing toolbox of related experimental techniques, engram manipulation has become a central topic in behavioral, systems, and molecular neuroscience. Recent research on the topic has provided novel insights into the mechanisms of long-term memory storage, and its overlap with instinct. We propose that memory and instinct may be embodied as isomorphic topological structures within the brain's microanatomical circuitry.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem
/
Memória
Idioma:
En
Revista:
Curr Opin Neurobiol
Assunto da revista:
BIOLOGIA
/
NEUROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article