Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective.
Cell Metab
; 33(4): 721-731, 2021 04 06.
Article
em En
| MEDLINE
| ID: mdl-33826915
ABSTRACT
Tremendous progress has been made over the last two decades in the field of pancreatic beta cell replacement therapy as a curative measure for diabetes. Transplantation studies have demonstrated therapeutic efficacy, and cGMP-grade cell products are currently being deployed for the first time in human clinical trials. In this perspective, we discuss current challenges surrounding the generation, delivery, and engraftment of stem cell-derived islet-like cells, along with strategies to induce durable tolerance to grafted cells, with an eye toward a functional cellular-based therapy enabling insulin independence for patients with diabetes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medicina Regenerativa
/
Insulina
Limite:
Humans
Idioma:
En
Revista:
Cell Metab
Assunto da revista:
METABOLISMO
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Canadá