CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion.
Blood
; 137(23): 3225-3236, 2021 06 10.
Article
em En
| MEDLINE
| ID: mdl-33827115
ABSTRACT
Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and antibody blocking of CD27 interaction with CD70 cause uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T-cell expansion and composition are unaltered after antibody blocking of CD27, only some EBV-specific CD8+ T-cell responses, exemplified by early lytic EBV antigen BMLF1-specific CD8+ T cells, are inhibited in their proliferation and killing of EBV-transformed B cells. This suggests that CD27 is not required for all CD8+ T-cell expansions and cytotoxicity but is required for a subset of CD8+ T-cell responses that protect us from EBV pathology.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
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Transativadores
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Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral
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Herpesvirus Humano 4
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Linfócitos T CD8-Positivos
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Infecções por Vírus Epstein-Barr
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Imunidade Celular
Limite:
Animals
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Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
2021
Tipo de documento:
Article