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Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer.
Singhal, Deepak; Hahn, Christopher N; Feurstein, Simone; Wee, Li Yan A; Moma, Luke; Kutyna, Monika M; Chhetri, Rakchha; Eshraghi, Leila; Schreiber, Andreas W; Feng, Jinghua; Wang, Paul P-S; Babic, Milena; Parker, Wendy T; Gao, Song; Moore, Sarah; Das, Soma; Thomas, David; Pattnaik, Swetansu; Brown, Anna L; D'Andrea, Richard J; Poplawski, Nicola K; Thomas, Daniel; Scott, Hamish S; Godley, Lucy A; Hiwase, Devendra K.
Afiliação
  • Singhal D; Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
  • Hahn CN; Department of Haematology, Royal Adelaide Hospital, Central Adelaide Local Health Network Adelaide, Adelaide, SA, Australia.
  • Feurstein S; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
  • Wee LYA; Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
  • Moma L; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia.
  • Kutyna MM; Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
  • Chhetri R; Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA.
  • Eshraghi L; Department of Haematology, Royal Adelaide Hospital, Central Adelaide Local Health Network Adelaide, Adelaide, SA, Australia.
  • Schreiber AW; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
  • Feng J; Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA.
  • Wang PP; Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
  • Babic M; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
  • Parker WT; Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
  • Gao S; Department of Haematology, Royal Adelaide Hospital, Central Adelaide Local Health Network Adelaide, Adelaide, SA, Australia.
  • Moore S; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
  • Das S; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia.
  • Thomas D; Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
  • Pattnaik S; Australian Cancer Research Foundation Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia.
  • Brown AL; Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
  • D'Andrea RJ; Australian Cancer Research Foundation Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia.
  • Poplawski NK; School of Molecular and Biological Sciences, University of Adelaide, Adelaide, SA, Australia.
  • Thomas D; Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
  • Scott HS; Australian Cancer Research Foundation Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia.
  • Godley LA; School of Molecular and Biological Sciences, University of Adelaide, Adelaide, SA, Australia.
  • Hiwase DK; Australian Cancer Research Foundation Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia.
Leukemia ; 35(11): 3245-3256, 2021 11.
Article em En | MEDLINE | ID: mdl-33850299
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Proteína Supressora de Tumor p53 / Mutação em Linhagem Germinativa / Neoplasias Hematológicas / Proteína BRCA1 / Proteína BRCA2 / Neoplasias Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Proteína Supressora de Tumor p53 / Mutação em Linhagem Germinativa / Neoplasias Hematológicas / Proteína BRCA1 / Proteína BRCA2 / Neoplasias Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália