New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D<sub>2</sub> receptor regulation and signaling.

Mann, Anika; Keen, Alastair C; Mark, Hanka; Dasgupta, Pooja; Javitch, Jonathan A; Canals, Meritxell; Schulz, Stefan; Robert Lane, J

New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D₂ receptor regulation and signaling.

Mann, Anika; Keen, Alastair C; Mark, Hanka; Dasgupta, Pooja; Javitch, Jonathan A; Canals, Meritxell; Schulz, Stefan; Robert Lane, J.

Afiliação

Mann A; Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
Keen AC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Mark H; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Dasgupta P; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, Midlands, UK.
Javitch JA; Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
Canals M; Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
Schulz S; Departments of Psychiatry and Pharmacology, Vagelos College of Physicians and Surgeons, Columbia University, New York, USA.
Robert Lane J; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, USA.

Sci Rep ; 11(1): 8288, 2021 04 15.

Article em En | MEDLINE | ID: mdl-33859231

Assuntos

Quinases de Receptores Acoplados a Proteína G/metabolismo; Receptores de Dopamina D2/metabolismo; Transdução de Sinais/genética; Transdução de Sinais/fisiologia; Anticorpos; Arrestinas/metabolismo; Quinases de Receptores Acoplados a Proteína G/imunologia; Células HEK293; Humanos; Terapia de Alvo Molecular; Doença de Parkinson/tratamento farmacológico; Doença de Parkinson/genética; Fosforilação; Receptores de Dopamina D2/agonistas; Receptores de Dopamina D2/imunologia; Esquizofrenia/tratamento farmacológico; Esquizofrenia/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores de Dopamina D2 / Quinases de Receptores Acoplados a Proteína G Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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