Mitochondrial DNA mutations contribute to high altitude pulmonary edema via increased oxidative stress and metabolic reprogramming during hypobaric hypoxia.

Sharma, Swati; Singh, Yamini; Sandhir, Rajat; Singh, Sayar; Ganju, Lilly; Kumar, Bhuvnesh; Varshney, Rajeev

Sharma, Swati; Singh, Yamini; Sandhir, Rajat; Singh, Sayar; Ganju, Lilly; Kumar, Bhuvnesh; Varshney, Rajeev.

Afiliação

Sharma S; Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Lucknow Road, Timarpur, Delhi 110054, India; Department of Biochemistry, Basic Medical Sciences Block II, Panjab University, Chandigarh 160014, India.
Singh Y; Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Lucknow Road, Timarpur, Delhi 110054, India. Electronic address: ysingh@dipas.drdo.in.
Sandhir R; Department of Biochemistry, Basic Medical Sciences Block II, Panjab University, Chandigarh 160014, India.
Singh S; Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Lucknow Road, Timarpur, Delhi 110054, India.
Ganju L; Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Lucknow Road, Timarpur, Delhi 110054, India.
Kumar B; Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Lucknow Road, Timarpur, Delhi 110054, India.
Varshney R; Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Lucknow Road, Timarpur, Delhi 110054, India.

Biochim Biophys Acta Bioenerg ; 1862(8): 148431, 2021 08 01.

Article em En | MEDLINE | ID: mdl-33862004

Assuntos

Altitude; Reprogramação Celular; DNA Mitocondrial/genética; Hipóxia/fisiopatologia; Mitocôndrias/genética; Mutação; Estresse Oxidativo; Edema Pulmonar/patologia; Adulto; Estudos de Casos e Controles; Humanos; Masculino; Mitocôndrias/patologia; Edema Pulmonar/etiologia

Palavras-chave

HAPE; Hypobaric hypoxia; Mitochondria; Oxidative phosphorylation; Oxidative stress; mtDNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Edema Pulmonar / DNA Mitocondrial / Estresse Oxidativo / Reprogramação Celular / Altitude / Hipóxia / Mitocôndrias / Mutação Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Biochim Biophys Acta Bioenerg Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia

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