Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and intensity.
Cell Mol Life Sci
; 78(12): 5083-5094, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33871677
ABSTRACT
Sound signals are acquired and digitized in the cochlea by the hair cells that further transmit the coded information to the central auditory pathways. Any defect in hair cell function may induce problems in the auditory system and hearing-based brain function. In the past 2 decades, our understanding of auditory transduction has been substantially deepened because of advances in molecular, structural, and functional studies. Results from these experiments can be perfectly embedded in the previously established profile from anatomical, histological, genetic, and biophysical research. This review aims to summarize the progress on the molecular and cellular mechanisms of the mechano-electrical transduction (MET) channel in the cochlear hair cells, which is involved in the acquisition of sound frequency and intensity-the two major parameters of an acoustic cue. We also discuss recent studies on TMC1, the molecule likely to form the MET channel pore.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mecanotransdução Celular
/
Condutividade Elétrica
/
Células Ciliadas Auditivas
/
Audição
/
Potenciais da Membrana
/
Proteínas de Membrana
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Mol Life Sci
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China