Valproate but not levetiracetam slows the EEG alpha peak frequency - A pharmaco-EEG study.
Clin Neurophysiol
; 132(6): 1203-1208, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33875373
ABSTRACT
OBJECTIVE:
Studies of the effect of valproate (VPA) on the background EEG have shown varying results. Therefore, we compared the effect of VPA and levetiracetam (LEV) on the EEG alpha peak frequency (APF).METHODS:
We retrospectively examined the APF in resting-state EEG of patients undergoing inpatient video-EEG monitoring (VEM) during withdrawal of VPA or LEV. We assessed APF trends by computing linear fits across individual patients' APF as a function of consecutive days, and correlated the APF and daily antiseizure medication (ASM) doses on a single-patient and group level.RESULTS:
The APF in the VPA-group significantly increased over days with falling VPA doses (p = 0.005, n = 13), but did not change significantly in the LEV-group (p = 0.47, n = 18). APF correlated negatively with daily ASM doses in the VPA-group (average of r = -0.74 ± 0.12 across patients, p = 0.0039), but not in the LEV-group (average of r = -0.17 ± 0.18 across patients, p = 0.4072).CONCLUSIONS:
Our results suggest that VPA treatment slows the APF. This APF reduction correlates with the daily dose of VPA and is not present in LEV treatment.SIGNIFICANCE:
Our study identifies a VPA-related slowing of the APF even in patients without electroencephalographic or overt clinical signs of encephalopathy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Ácido Valproico
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Epilepsia
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Ritmo alfa
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Levetiracetam
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Anticonvulsivantes
Tipo de estudo:
Observational_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Neurophysiol
Assunto da revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article