FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy.

He, Chuan; Lu, Shan; Wang, Xuan-Zhong; Wang, Chong-Cheng; Wang, Lei; Liang, Shi-Peng; Luo, Tian-Fei; Wang, Zhen-Chuan; Piao, Mei-Hua; Chi, Guang-Fan; Ge, Peng-Fei

He, Chuan; Lu, Shan; Wang, Xuan-Zhong; Wang, Chong-Cheng; Wang, Lei; Liang, Shi-Peng; Luo, Tian-Fei; Wang, Zhen-Chuan; Piao, Mei-Hua; Chi, Guang-Fan; Ge, Peng-Fei.

Afiliação

He C; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.
Lu S; Research Center of Neuroscience, First Hospital of Jilin University, Changchun, 130021, China.
Wang XZ; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.
Wang CC; Research Center of Neuroscience, First Hospital of Jilin University, Changchun, 130021, China.
Wang L; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.
Liang SP; Research Center of Neuroscience, First Hospital of Jilin University, Changchun, 130021, China.
Luo TF; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.
Wang ZC; Research Center of Neuroscience, First Hospital of Jilin University, Changchun, 130021, China.
Piao MH; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.
Chi GF; Research Center of Neuroscience, First Hospital of Jilin University, Changchun, 130021, China.
Ge PF; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.

Acta Pharmacol Sin ; 42(8): 1324-1337, 2021 Aug.

Article em En | MEDLINE | ID: mdl-33879840

Assuntos

Antineoplásicos/uso terapêutico; Quebras de DNA de Cadeia Dupla/efeitos dos fármacos; Proteína Forkhead Box O3/metabolismo; Glioma/metabolismo; Mitofagia/efeitos dos fármacos; Temozolomida/uso terapêutico; Animais; Autofagia/efeitos dos fármacos; Linhagem Celular Tumoral; Glioma/tratamento farmacológico; Humanos; Proteínas de Membrana/metabolismo; Camundongos Endogâmicos BALB C; Camundongos Nus; Mitocôndrias/efeitos dos fármacos; Proteínas Mitocondriais/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Proteínas Proto-Oncogênicas/metabolismo; Ratos; Regulação para Cima/efeitos dos fármacos

Palavras-chave

3MA; BNIP3; DNA double strand break; FOXO3a; bafilomycin A; glioma; mitochondrial superoxide; mitophagy; oxidative stress; temozolomide

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quebras de DNA de Cadeia Dupla / Mitofagia / Proteína Forkhead Box O3 / Temozolomida / Glioma / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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