HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons.

Santerre, Maryline; Arjona, Sterling P; Allen, Charles Ns; Callen, Shannon; Buch, Shilpa; Sawaya, Bassel E

Santerre, Maryline; Arjona, Sterling P; Allen, Charles Ns; Callen, Shannon; Buch, Shilpa; Sawaya, Bassel E.

Afiliação

Santerre M; Molecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Arjona SP; Molecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Allen CN; Molecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Callen S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Buch S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Sawaya BE; Molecular Studies of Neurodegenerative Diseases Lab, FELS Cancer Institute for Personalized Medicine and Department of Neurology Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Autophagy ; 17(7): 1768-1782, 2021 07.

Article em En | MEDLINE | ID: mdl-33890542

Assuntos

Complexo AIDS Demência/etiologia; Lisossomos/virologia; Neurônios/virologia; alfa-Sinucleína/metabolismo; Produtos do Gene vpr do Vírus da Imunodeficiência Humana/metabolismo; Complexo AIDS Demência/metabolismo; Complexo AIDS Demência/patologia; Animais; Autofagossomos/virologia; Western Blotting; Encéfalo/patologia; Encéfalo/virologia; Imunofluorescência; HIV-1; Humanos; Lisossomos/fisiologia; Macaca mulatta; Camundongos; Camundongos Endogâmicos C57BL; Microscopia Eletrônica de Transmissão; Neurônios/metabolismo; Neurônios/fisiologia

Palavras-chave

Alpha-synuclein; HIV-1; Snapin; autophagy; lysosomes; motor dysfunction; neurons

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexo AIDS Demência / Alfa-Sinucleína / Produtos do Gene vpr do Vírus da Imunodeficiência Humana / Lisossomos / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Autophagy Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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