In vivo kinetics of canine leukocytes labeled with technetium-99m HM-PAO and indium-111 tropolonate.
J Nucl Med
; 29(7): 1246-51, 1988 Jul.
Article
em En
| MEDLINE
| ID: mdl-3392583
ABSTRACT
Two weeks after the introduction of osteomyelitis in three dogs, autologous leukocytes were dual-labeled with both [99mTc]HM-PAO and [111In]tropolonate, and reinjected. Blood sampling and imaging were then performed. Two weeks later, the same dogs received simultaneous injections of singly-labeled [99mTc]WBC and [111In]WBC for comparison. For both studies, blood samples were drawn over 6 hr to determine the respective blood clearance half-time (TB) and % recovery (%R0) of cell-bound radioactivity. There were no significant differences in the average TB results of the 99mTc and 111In groups, either within or between the dual- and singly-labeled studies. The %R0 of singly-labeled [99mTc]WBC was about half that of the other groups (p less than 0.01); however, this difference was attributed to the dissimilar radiochemical purity of the [99mTc]HM-PAO reagents. Region of interest analysis of the 6 and 24 hr images revealed no significant differences between either cell label in the relative or absolute in vivo uptake at known sites of osteomyelitis, noninfected surgery, and normal bone marrow.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Oximas
/
Tropolona
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Radioisótopos de Índio
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Tecnécio
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Cicloeptanos
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Leucócitos
Limite:
Animals
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
1988
Tipo de documento:
Article