Tentative fMRI signatures of perceptual echoes in early visual cortex.

ABSTRACT

The visual Impulse Response Function (IRF) can be estimated by cross-correlating random luminance sequences with concurrently recorded EEG. It typically contains a strong 10 Hz oscillatory component, suggesting that visual information reverberates in the human brain as a "perceptual echo". The neural origin of these echoes remains unknown. To address this question, we recorded EEG and fMRI in two separate sessions. In both sessions, a disk whose luminance followed a random (white noise) sequence was presented in the upper left quadrant. Individual IRFs were derived from the EEG session. These IRFs were then used as "response templates" to reconstruct an estimate of the EEG during the fMRI session, by convolution with the corresponding random luminance sequences. The 7-14 Hz (alpha, the main frequency component of the IRF) envelope of the reconstructed EEG was finally used as an fMRI regressor, to determine which brain voxels co-varied with the oscillations elicited by the luminance sequence, i.e., the "perceptual echoes". The reconstructed envelope of EEG alpha was significantly correlated with BOLD responses in V1 and V2. Surprisingly, this correlation was visible outside, but not within the directly (retinotopically) stimulated region. We tentatively interpret this lack of alpha modulation as a BOLD saturation effect, since the overall stimulus-induced BOLD response was inversely related, across voxels, to the signal variability over time. In conclusion, our results suggest that perceptual echoes originate in early visual cortex, driven by widespread activity in V1 and V2, not retinotopically restricted, but possibly reflecting the propagation of a travelling alpha wave.