Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines.

Parczyk, Jonas; Ruhnau, Jérôme; Pelz, Carsten; Schilling, Max; Wu, Hao; Piaskowski, Nicole Nadine; Eickholt, Britta; Kühn, Hartmut; Danker, Kerstin; Klein, Andreas

Parczyk, Jonas; Ruhnau, Jérôme; Pelz, Carsten; Schilling, Max; Wu, Hao; Piaskowski, Nicole Nadine; Eickholt, Britta; Kühn, Hartmut; Danker, Kerstin; Klein, Andreas.

Afiliação

Parczyk J; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany. jonasparczyk@outlook.com.
Ruhnau J; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany. jerome.ruhnau@gmail.com.
Pelz C; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Schilling M; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Wu H; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Piaskowski NN; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Eickholt B; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Kühn H; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Danker K; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Klein A; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.

BMC Cancer ; 21(1): 481, 2021 Apr 30.

Article em En | MEDLINE | ID: mdl-33931028

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Linhagem Celular Tumoral/efeitos dos fármacos; Ácido Dicloroacético/farmacologia; Compostos de Mostarda/farmacologia; Fenilpropionatos/farmacologia; Células A549; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais/métodos; Sinergismo Farmacológico; Células HT29; Células HeLa; Humanos; Células MCF-7; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Cancer cell lines; Cancer therapy; Dichloroacetate; Drug combination; HIF-1α inhibition; Metabolism; PX-478; Synergism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilpropionatos / Compostos de Mostarda / Protocolos de Quimioterapia Combinada Antineoplásica / Linhagem Celular Tumoral / Ácido Dicloroacético Limite: Humans Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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