Molecular Mechanism of Thymidylate Synthase Inhibition by N<sup>4</sup>-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies.

Maj, Piotr; Jarmula, Adam; Wilk, Piotr; Prokopowicz, Malgorzata; Rypniewski, Wojciech; Zielinski, Zbigniew; Dowiercial, Anna; Bzowska, Agnieszka; Rode, Wojciech

Molecular Mechanism of Thymidylate Synthase Inhibition by N⁴-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies.

Maj, Piotr; Jarmula, Adam; Wilk, Piotr; Prokopowicz, Malgorzata; Rypniewski, Wojciech; Zielinski, Zbigniew; Dowiercial, Anna; Bzowska, Agnieszka; Rode, Wojciech.

Afiliação

Maj P; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.
Jarmula A; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.
Wilk P; Helmholtz-Zentrum Berlin, Macromolecular Crystallography (NP-GMX) Elektronenspeicherring BESSY II, 15 Albert-Einstein-St., D-12489 Berlin, Germany.
Prokopowicz M; College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences and Faculty of Physics, University of Warsaw, PL-02-097 Warszawa, Poland.
Rypniewski W; Institute of Bioorganic Chemistry, Polish Academy of Sciences, PL- 61-704 Poznan, Poland.
Zielinski Z; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.
Dowiercial A; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.
Bzowska A; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, PL-02-093 Warszawa, Poland.
Rode W; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.

Int J Mol Sci ; 22(9)2021 Apr 30.

Article em En | MEDLINE | ID: mdl-33946210

Assuntos

Desoxicitidina Monofosfato/análogos & derivados; Inibidores Enzimáticos/farmacologia; Timidilato Sintase/antagonistas & inibidores; Trichinella/enzimologia; Animais; Cristalografia por Raios X; Desoxicitidina Monofosfato/química; Desoxicitidina Monofosfato/farmacologia; Inibidores Enzimáticos/química; Humanos; Camundongos; Simulação de Acoplamento Molecular; Espectrofotometria; Timidilato Sintase/química; Timidilato Sintase/metabolismo; Triquinelose/parasitologia

Palavras-chave

N4-hydroxy-dCMP binding; dihydrofolate production; imidazolidine ring opening; thymidylate synthase

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Timidilato Sintase / Trichinella / Desoxicitidina Monofosfato / Inibidores Enzimáticos Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Polônia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google