Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study.

Cascino, Gregory D; Tarquinio, Daniel; Wheless, James W; Hogan, R Edward; Sperling, Michael R; Liow, Kore; Desai, Jay; Davis, Charles; Rabinowicz, Adrian L; Carrazana, Enrique

Cascino, Gregory D; Tarquinio, Daniel; Wheless, James W; Hogan, R Edward; Sperling, Michael R; Liow, Kore; Desai, Jay; Davis, Charles; Rabinowicz, Adrian L; Carrazana, Enrique.

Afiliação

Cascino GD; Mayo Clinic, Rochester, MN, USA. Electronic address: gcascino@mayo.edu.
Tarquinio D; Center for Rare Neurological Diseases, Atlanta, GA, USA.
Wheless JW; Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TN, USA.
Hogan RE; Washington University in St. Louis, St. Louis, MO, USA.
Sperling MR; Thomas Jefferson University, Philadelphia, PA, USA.
Liow K; Hawaii Pacific Neuroscience, Honolulu, HI, USA.
Desai J; Children's Hospital of Los Angeles, CA, USA.
Davis C; SD Biostatistics, Inc., Oro Valley, AZ, USA.
Rabinowicz AL; Neurelis, Inc., San Diego, CA, USA.
Carrazana E; Neurelis, Inc., San Diego, CA, USA.

Epilepsy Behav ; 120: 107983, 2021 07.

Article em En | MEDLINE | ID: mdl-33957437

Assuntos

Diazepam; Epilepsia; Sprays Nasais; Administração Intranasal; Diazepam/uso terapêutico; Epilepsia/tratamento farmacológico; Humanos; Convulsões/tratamento farmacológico; Resultado do Tratamento

Palavras-chave

Benzodiazepines; Diazepam nasal spray; Rescue therapy; Seizure clusters; Tolerance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diazepam / Epilepsia / Sprays Nasais Limite: Humans Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article

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