The landscape of cell-cell communication through single-cell transcriptomics.
Curr Opin Syst Biol
; 26: 12-23, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33969247
ABSTRACT
Cell-cell communication is a fundamental process that shapes biological tissue. Historically, studies of cell-cell communication have been feasible for one or two cell types and a few genes. With the emergence of single-cell transcriptomics, we are now able to examine the genetic profiles of individual cells at unprecedented scale and depth. The availability of such data presents an exciting opportunity to construct a more comprehensive description of cell-cell communication. This review discusses the recent explosion of methods that have been developed to infer cell-cell communication from non-spatial and spatial single-cell transcriptomics, two promising technologies which have complementary strengths and limitations. We propose several avenues to propel this rapidly expanding field forward in meaningful ways.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Curr Opin Syst Biol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos