Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection.

Zhang, Wenlong; Chen, Huaqing; Ding, Liuyan; Gong, Junwei; Zhang, Mengran; Guo, Wenyuan; Xu, Pingyi; Li, Shiying; Zhang, Yunlong

Zhang, Wenlong; Chen, Huaqing; Ding, Liuyan; Gong, Junwei; Zhang, Mengran; Guo, Wenyuan; Xu, Pingyi; Li, Shiying; Zhang, Yunlong.

Afiliação

Zhang W; Department of Neurology The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China.
Chen H; Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences & The Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 China.
Ding L; Department of Neurology The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China.
Gong J; Key Laboratory of Neurological Function and Health School of Basic Medical Sciences Guangzhou Medical University Guangzhou 511436 China.
Zhang M; Key Laboratory of Neurological Function and Health School of Basic Medical Sciences Guangzhou Medical University Guangzhou 511436 China.
Guo W; Department of Neurology The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China.
Xu P; Department of Neurology The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China.
Li S; Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences & The Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 China.
Zhang Y; Key Laboratory of Neurological Function and Health School of Basic Medical Sciences Guangzhou Medical University Guangzhou 511436 China.

Adv Sci (Weinh) ; 8(9): 2004555, 2021 05.

Article em En | MEDLINE | ID: mdl-33977069

Assuntos

Chalcona/análogos & derivados; Chalcona/administração & dosagem; Sistemas de Liberação de Medicamentos/métodos; Fármacos Neuroprotetores/administração & dosagem; Doença de Parkinson/tratamento farmacológico; Animais; Barreira Hematoencefálica/metabolismo; Chalcona/uso terapêutico; Modelos Animais de Doenças; Camundongos; Camundongos Endogâmicos C57BL; Fármacos Neuroprotetores/uso terapêutico; Substância Negra/efeitos dos fármacos; Substância Negra/metabolismo

Palavras-chave

DMC; TH ubiquitination; blood brain barrier; brain targeted delivery; neuroinflammation; oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Chalcona / Sistemas de Liberação de Medicamentos / Fármacos Neuroprotetores Limite: Animals Idioma: En Revista: Adv Sci (Weinh) Ano de publicação: 2021 Tipo de documento: Article

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