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Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.
Krystufek, Robin; Sácha, Pavel; Starková, Jana; Brynda, Jirí; Hradilek, Martin; Tloust'ová, Eva; Grzymska, Justyna; Rut, Wioletta; Boucher, Michael J; Drag, Marcin; Majer, Pavel; Hájek, Miroslav; Rezácová, Pavlína; Madhani, Hiten D; Craik, Charles S; Konvalinka, Jan.
Afiliação
  • Krystufek R; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic.
  • Sácha P; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles UniversityHlavova 8, Prague 2 12843, Czech Republic.
  • Starková J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic.
  • Brynda J; Department of Biochemistry, Faculty of Science, Charles UniversityHlavova 8, Prague 2 12843, Czech Republic.
  • Hradilek M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic.
  • Tloust'ová E; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic.
  • Grzymska J; Institute of Molecular Genetics of the Czech Academy of Sciences, Vídenská 1083, Prague 4 14220, Czech Republic.
  • Rut W; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic.
  • Boucher MJ; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic.
  • Drag M; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, Wroclaw 50-370, Poland.
  • Majer P; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, Wroclaw 50-370, Poland.
  • Hájek M; Department of Biochemistry & Biophysics, University of California, San Francisco, UCSF Genentech Hall, 600 16th St Rm N374, San Francisco, California 94158, United States.
  • Rezácová P; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, Wroclaw 50-370, Poland.
  • Madhani HD; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic.
  • Craik CS; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic.
  • Konvalinka J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic.
J Med Chem ; 64(10): 6706-6719, 2021 05 27.
Article em En | MEDLINE | ID: mdl-34006103
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Fúngicas / Cryptococcus neoformans / Ácido Aspártico Proteases / Antifúngicos Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: República Tcheca
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Fúngicas / Cryptococcus neoformans / Ácido Aspártico Proteases / Antifúngicos Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: República Tcheca