Discovery of novel iminosydnone compounds with insecticidal activities based on the binding mode of triflumezopyrim.

Du, Shaoqing; Hu, Xueping; Li, Mengnan; Jiang, Xiaoqun; Xu, Xiaoyong; Cheng, Jiagao; Qian, Xuhong

Du, Shaoqing; Hu, Xueping; Li, Mengnan; Jiang, Xiaoqun; Xu, Xiaoyong; Cheng, Jiagao; Qian, Xuhong.

Afiliação

Du S; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Hu X; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Li M; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Jiang X; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Xu X; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Cheng J; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address: jgcheng@ecust.edu.cn.
Qian X; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China. Electronic address: xhqian@ecust.edu.cn.

Bioorg Med Chem Lett ; 46: 128120, 2021 08 15.

Article em En | MEDLINE | ID: mdl-34015502

Assuntos

Descoberta de Drogas; Inseticidas/farmacologia; Mariposas/efeitos dos fármacos; Piridinas/farmacologia; Pirimidinonas/farmacologia; Sidnonas/farmacologia; Animais; Relação Dose-Resposta a Droga; Inseticidas/síntese química; Inseticidas/química; Estrutura Molecular; Piridinas/química; Pirimidinonas/química; Relação Estrutura-Atividade; Sidnonas/síntese química; Sidnonas/química

Palavras-chave

Computer aided drug design; Iminosydnone; Insecticidal activities; Mesoionic; Triflumezopyrim

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Pirimidinonas / Sidnonas / Descoberta de Drogas / Inseticidas / Mariposas Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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