Modifying role of vitamins on the mutagenic action of N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis
; 9(8): 1513-5, 1988 Aug.
Article
em En
| MEDLINE
| ID: mdl-3402049
ABSTRACT
Several vitamin compounds have been tested for their ability to suppress the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine, a direct acting mutagen/carcinogen, in Salmonella typhimurium strain TA100. Menadione, alpha-tocopherol, retinal and retinol have displayed high inhibitory activity. The antimutagenic activity of menadione, in particular, has been found to be remarkable in as much as less than equimolar amount can reduce the mutagenic potency of the carcinogen by 50%. In vitro data suggest that its action is mediated by accelerating the deactivation of the N-nitroso carcinogen, possibly involving the formation of a quinone radical.
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Base de dados:
MEDLINE
Assunto principal:
Vitaminas
/
Metilnitronitrosoguanidina
/
Mutagênicos
Idioma:
En
Revista:
Carcinogenesis
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Índia