Filgrastim alone versus cyclophosphamide and filgrastim for mobilization in multiple myeloma patients.
Transfus Apher Sci
; 60(4): 103159, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-34034961
ABSTRACT
BACKGROUND AND OBJECTIVE:
High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is standard treatment approach in most multiple myeloma (MM) patients. Before ASCT, chemomobilization or only granulocyte-colony stimulating factor (G-CSF) mobilization can be preferred in stem cell mobilization. The primary aim of the study is to compare the effect of the two mobilization regimens on hematopoietic engraftment times, CD34+cell counts and number of apheresis required to harvest stem cells. MATERIALS ANDMETHODS:
The records of MM patients who applied to our hospital between 2010 and 2020 were analysed retrospectively. Patients were divided into two groups (Group A Cyclophosphamide plus filgrastim, Group B Filgrastim alone) according to the mobilization regimen.RESULTS:
A total of 223 MM patients were included in this study (Group A153, Group B70 patients). When the patients in Group A and Group B were compared, the number of collected CD34+ cells were higher in Group A (p < 0.001). However, there was no significant difference between the two groups in terms of median times to neutrophil and platelet engraftment, and number of apheresis required to harvest stem cells (p > 0.05). The rate of infection development during mobilization in the patients in group A and the duration of hospitalization of these patients were higher than the patients in group B (p < 0.001). Patients receiving >6 cycles of chemotherapy and immunomodulatory treatment had lower collected CD34+ cells than other patients (p = 0.012 and p = 0.054).CONCLUSION:
Based on our findings, filgrastim alone seems to provide a sufficient amount of stem cells in MM patients.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Mobilização de Células-Tronco Hematopoéticas
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Ciclofosfamida
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Transplante de Células-Tronco de Sangue Periférico
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Filgrastim
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Mieloma Múltiplo
Tipo de estudo:
Observational_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Transfus Apher Sci
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article