Protective Effect of Aldo-keto Reductase 1B1 Against Neuronal Cell Damage Elicited by 4'-Fluoro-&#945;-pyrrolidinononanophenone.

Morikawa, Yoshifumi; Miyazono, Hidetoshi; Kamase, Kyoko; Suenami, Koichi; Sasajima, Yasuhide; Sato, Kiyohito; Endo, Satoshi; Monguchi, Yasunari; Takekoshi, Yuji; Ikari, Akira; Matsunaga, Toshiyuki

Protective Effect of Aldo-keto Reductase 1B1 Against Neuronal Cell Damage Elicited by 4'-Fluoro-α-pyrrolidinononanophenone.

Morikawa, Yoshifumi; Miyazono, Hidetoshi; Kamase, Kyoko; Suenami, Koichi; Sasajima, Yasuhide; Sato, Kiyohito; Endo, Satoshi; Monguchi, Yasunari; Takekoshi, Yuji; Ikari, Akira; Matsunaga, Toshiyuki.

Afiliação

Morikawa Y; Forensic Science Laboratory, Gifu Prefectural Police Headquarters, Gifu, Japan.
Miyazono H; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, Japan.
Kamase K; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, Japan.
Suenami K; Forensic Science Laboratory, Gifu Prefectural Police Headquarters, Gifu, Japan.
Sasajima Y; Forensic Science Laboratory, Gifu Prefectural Police Headquarters, Gifu, Japan.
Sato K; Forensic Science Laboratory, Gifu Prefectural Police Headquarters, Gifu, Japan.
Endo S; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, Japan.
Monguchi Y; Laboratory of Organic Chemistry, Daiichi University of Pharmacy, Fukuoka, Japan.
Takekoshi Y; Forensic Science Laboratory, Gifu Prefectural Police Headquarters, Gifu, Japan.
Ikari A; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, Japan.
Matsunaga T; Education Center of Green Pharmaceutical Sciences, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, 502-8585, Japan. matsunagat@gifu-pu.ac.jp.

Neurotox Res ; 39(4): 1360-1371, 2021 Aug.

Article em En | MEDLINE | ID: mdl-34043181

Assuntos

Aldeído Redutase/biossíntese; Butirofenonas/toxicidade; Drogas Desenhadas/toxicidade; Neurônios/efeitos dos fármacos; Neurônios/enzimologia; Neuroproteção/fisiologia; Pirrolidinas/toxicidade; Aldeído Redutase/antagonistas & inibidores; Linhagem Celular Tumoral; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/farmacologia; Humanos; Naftalenos/farmacologia; Neurônios/patologia

Palavras-chave

4'-Fluoro-α-pyrrolidinononanophenone; Aldoketo reductase 1B1; Antioxidant properties; Neuronal cell; Reactive oxygen species

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinas / Butirofenonas / Drogas Desenhadas / Aldeído Redutase / Neuroproteção / Neurônios Limite: Humans Idioma: En Revista: Neurotox Res Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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