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Exploring protein hotspots by optimized fragment pharmacophores.
Bajusz, Dávid; Wade, Warren S; Satala, Grzegorz; Bojarski, Andrzej J; Ilas, Janez; Ebner, Jessica; Grebien, Florian; Papp, Henrietta; Jakab, Ferenc; Douangamath, Alice; Fearon, Daren; von Delft, Frank; Schuller, Marion; Ahel, Ivan; Wakefield, Amanda; Vajda, Sándor; Gerencsér, János; Pallai, Péter; Keseru, György M.
Afiliação
  • Bajusz D; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Budapest, Hungary.
  • Wade WS; BioBlocks, Inc., San Diego, CA, USA.
  • Satala G; Maj Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
  • Bojarski AJ; Maj Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
  • Ilas J; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
  • Ebner J; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
  • Grebien F; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
  • Papp H; National Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
  • Jakab F; National Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
  • Douangamath A; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, UK.
  • Fearon D; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, OX11 0FA, UK.
  • von Delft F; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, UK.
  • Schuller M; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, OX11 0FA, UK.
  • Ahel I; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, UK.
  • Wakefield A; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, OX11 0FA, UK.
  • Vajda S; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK.
  • Gerencsér J; Centre for Medicines Discovery, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK.
  • Pallai P; Department of Biochemistry, University of Johannesburg, Auckland Park, 2006, South Africa.
  • Keseru GM; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Nat Commun ; 12(1): 3201, 2021 05 27.
Article em En | MEDLINE | ID: mdl-34045440
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histona-Lisina N-Metiltransferase / Descoberta de Drogas / Ensaios de Triagem em Larga Escala / Desenvolvimento de Medicamentos / Proteases 3C de Coronavírus / Proteases Semelhantes à Papaína de Coronavírus Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Hungria
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histona-Lisina N-Metiltransferase / Descoberta de Drogas / Ensaios de Triagem em Larga Escala / Desenvolvimento de Medicamentos / Proteases 3C de Coronavírus / Proteases Semelhantes à Papaína de Coronavírus Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Hungria