Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III.
Tetrahedron Lett
; 712021 May 11.
Article
em En
| MEDLINE
| ID: mdl-34054153
ABSTRACT
Rhodojaponin III is a grayanane-type diterpenoid natural product with a novel chemical scaffold. It shows potent antinociceptive activity and may represent a new class of natural non-opioid analgesics with a novel mode of action. We explored the Au(I)-catalyzed Conia-ene cyclization and the Mn(III)-mediated radical cyclization of alkynyl ketones for the synthesis of the bicyclo[3.2.1]octane fragment of rhodojaponin III. These strategies will be applicable in the synthesis of rhodojaponin III and analogs for future biological studies.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos