Folding Control in the Path of Type 5 Secretion.
Toxins (Basel)
; 13(5)2021 05 11.
Article
em En
| MEDLINE
| ID: mdl-34064645
ABSTRACT
The type 5 secretion system (T5SS) is one of the more widespread secretion systems in Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins, adhesins, enzymes) and include numerous virulence factors. Mechanistically, the T5SS has long been considered the simplest of secretion systems, due to the paucity of proteins required for its functioning. Still, despite more than two decades of study, the exact process by which T5SS substrates attain their final destination and correct conformation is not totally deciphered. Moreover, the recent addition of new sub-families to the T5SS raises additional questions about this secretion mechanism. Central to the understanding of type 5 secretion is the question of protein folding, which needs to be carefully controlled in each of the bacterial cell compartments these proteins cross. Here, the biogenesis of proteins secreted by the Type 5 secretion system is discussed, with a focus on the various factors preventing or promoting protein folding during biogenesis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dobramento de Proteína
/
Sistemas de Secreção Tipo V
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Bactérias Gram-Negativas
Idioma:
En
Revista:
Toxins (Basel)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
França