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Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
Du, Daohai; Xu, Dandan; Zhu, Licheng; Stazi, Giulia; Zwergel, Clemens; Liu, Yanli; Luo, Zhongyuan; Li, Yuanqing; Zhang, Yuanyuan; Zhu, Kongkai; Ding, Yiluan; Liu, Jingqiu; Fan, Shijie; Zhao, Kaiyan; Zhang, Naixia; Kong, Xiangqian; Jiang, Hualiang; Chen, Kaixian; Zhao, Kehao; Valente, Sergio; Min, Jinrong; Duan, Wenhu; Luo, Cheng.
Afiliação
  • Du D; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023 Jiangsu, China.
  • Xu D; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 210203, China.
  • Zhu L; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Stazi G; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Zwergel C; Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto M5G1L7 Ontario, Canada.
  • Liu Y; Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, China.
  • Luo Z; School of Life Sciences, Jinggangshan University, Ji'an 343009 Jiangxi, China.
  • Li Y; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome 00185, Italy.
  • Zhang Y; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome 00185, Italy.
  • Zhu K; Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto M5G1L7 Ontario, Canada.
  • Ding Y; Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, China.
  • Liu J; College of Pharmaceutical Sciences, Soochow University, Suzhou 215123 Jiangsu, China.
  • Fan S; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023 Jiangsu, China.
  • Zhao K; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 210203, China.
  • Zhang N; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 210203, China.
  • Kong X; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Jiang H; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 210203, China.
  • Chen K; School of Biological Science and Technology, University of Jinan; Jinan 250022, China.
  • Zhao K; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Valente S; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 210203, China.
  • Min J; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 210203, China.
  • Duan W; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Luo C; University of Chinese Academy of Sciences, Beijing 100049, China.
J Med Chem ; 64(12): 8194-8207, 2021 06 24.
Article em En | MEDLINE | ID: mdl-34077206
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ligação Proteica / Astemizol / Inibidores Enzimáticos / Complexo Repressor Polycomb 2 / Proteína Potenciadora do Homólogo 2 de Zeste Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ligação Proteica / Astemizol / Inibidores Enzimáticos / Complexo Repressor Polycomb 2 / Proteína Potenciadora do Homólogo 2 de Zeste Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China