The Functional Role of Oncogenic LncRNA BCAR4 for Cancer Outcome.
Curr Pharm Des
; 27(39): 4107-4113, 2021.
Article
em En
| MEDLINE
| ID: mdl-34086548
ABSTRACT
BACKGROUND:
Long non-coding RNA (lncRNA) breast cancer anti-estrogen resistance 4 (BCAR4) is a characterized oncogenic lncRNA in different cancers. This review is dedicated to summarize various molecular mechanisms of BCAR4 and demonstrate that the biological functions exerted by BCAR4 are good entry points for therapy.METHODS:
The molecular mechanism of BCAR4 acting on tumors is summarized by reviewing PubMed.RESULTS:
The expression of lncRNA BCAR4 is abnormally increased in all kinds of tumors, including colorectal cancer, prostate cancer, bladder cancer, gastric cancer, chondrosarcoma, glioma, breast cancer, glioma, gastric cancer, liver cancer, cervical cancer, lung cancer, etc. Besides, BCAR4 mediates multiple processes involved in carcinogenesis, including proliferation, invasion, anti-apoptosis, migration.CONCLUSION:
BCAR4 may show great clinical value in this direction as a therapeutic cancer target.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Longo não Codificante
/
Neoplasias Pulmonares
Limite:
Humans
/
Male
Idioma:
En
Revista:
Curr Pharm Des
Assunto da revista:
FARMACIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China