HIF-1α in the Crosstalk Between Reactive Oxygen Species and Autophagy Process: A Review in Multiple Sclerosis.
Cell Mol Neurobiol
; 42(7): 2121-2129, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-34089426
ABSTRACT
Cellular stress can lead to the production of reactive oxygen species (ROS) while autophagy, as a catabolic pathway, protects the cells against stress. Autophagy in its turn plays a pivotal role in the pathophysiology of multiple sclerosis (MS). In the current review, we first summarized the contribution of ROS and autophagy to MS pathogenesis. Then probable crosstalk between these two pathways through HIF-1α for the first time has been proposed with the hope of employing a better understanding of MS pathophysiology and probable therapeutic approaches.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esclerose Múltipla
Limite:
Humans
Idioma:
En
Revista:
Cell Mol Neurobiol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Irã