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Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers.
Rujas, Edurne; Kucharska, Iga; Tan, Yong Zi; Benlekbir, Samir; Cui, Hong; Zhao, Tiantian; Wasney, Gregory A; Budylowski, Patrick; Guvenc, Furkan; Newton, Jocelyn C; Sicard, Taylor; Semesi, Anthony; Muthuraman, Krithika; Nouanesengsy, Amy; Aschner, Clare Burn; Prieto, Katherine; Bueler, Stephanie A; Youssef, Sawsan; Liao-Chan, Sindy; Glanville, Jacob; Christie-Holmes, Natasha; Mubareka, Samira; Gray-Owen, Scott D; Rubinstein, John L; Treanor, Bebhinn; Julien, Jean-Philippe.
Afiliação
  • Rujas E; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Kucharska I; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
  • Tan YZ; Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao, Spain.
  • Benlekbir S; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Cui H; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Zhao T; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Wasney GA; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Budylowski P; Department of Immunology, University of Toronto, Toronto, ON, Canada.
  • Guvenc F; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Newton JC; The Structural & Biophysical Core Facility, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Sicard T; Combined Containment Level 3 Unit, University of Toronto, Toronto, ON, Canada.
  • Semesi A; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Muthuraman K; Combined Containment Level 3 Unit, University of Toronto, Toronto, ON, Canada.
  • Nouanesengsy A; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Aschner CB; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Prieto K; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Bueler SA; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
  • Youssef S; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Liao-Chan S; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Glanville J; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Christie-Holmes N; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
  • Mubareka S; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Gray-Owen SD; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Rubinstein JL; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Treanor B; Distributed Bio, South San Francisco, CA, USA.
  • Julien JP; Distributed Bio, South San Francisco, CA, USA.
Nat Commun ; 12(1): 3661, 2021 06 16.
Article em En | MEDLINE | ID: mdl-34135340
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes / SARS-CoV-2 / Anticorpos Monoclonais / Anticorpos Antivirais Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes / SARS-CoV-2 / Anticorpos Monoclonais / Anticorpos Antivirais Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá