ARIA, Ambiguous Restraints for Iterative Assignment; ATP modulation; BDNF, Brain Derived Neurotrophic Factor; CARA, Computer Aided Resonance Assignment; CS-E, Chrondroitin Sulfate E; CSP, Chemical Shift Perturbation; DSF, Differential Scanning Fluorimetry; EI-MS, Electron Ionization Mass Spectrometry; Endogenous ligands; FGF2, Fibroblast Growth Factor 2; FT-IR, Fourier Transform Infrared Spectroscopy; HBD, Heparin Binding Domain; HSQC, Heteronuclear Single Quantum Coherence; ITC, Isothermal Titration Calorimetry; MALDI-TOF MS, Matrix Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry; MD, Molecular Dynamics; MS, Mass Spectrometry; NGF interactions; NGF, Nerve Growth Factor; NMR, Nuclear Magnetic Resonance; NOE, Nuclear Overhouser Effect; NOESY, Nuclear Overhauser Effect Spectroscopy; NT, NeuroTrophin; Neurotrophins; P20, Polysorbate 20; PME, Particle Mesh Ewald; RMSD, Root Mean Square Deviation; SAR, Structure-Activity Relationship; SPR, Surface Plasmon Resonance; STD, Saturation-Transfer Difference; TrkA, Tyrosine Kinase Receptor A; TrkA, p75NTR receptors; p75NTR, p75 NeuroTrophin Receptor; proNGF, proNGF ­ NGF precursor; rh-proNGF, recombinant human proNGF ­ NGF precursor; rhNGF, recombinant human NGF; rmNGF, recombinant mouse NGF